Nicolas Berbari, Ph.D.Assistant Professor, Biology Department, Neuroscience Program
Current work in the lab focuses on the roles of small hair-like cellular appendages called cilia. We are particularly interested in their roles in the brain. Interestingly, when cilia are disrupted in the feeding centers of the brain this results in obesity in both mice and patients with genetic disorders that affect cilia function. We are currently trying to determine how cilia can affect appetite and satiety. We are utilizing conditional and congenital knockout mouse models, tissue culture, pharmacology and electrophysiology to address this question.
Publications & Professional Activities
Berbari N.F.#, Pasek R.C.#, Malarkey E.B., Yazdi S.M.Z. R., McNair A., Lewis W.R., Kesterson R.A., Nagy T., Yoder B.K. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci U S A. 2013 May 7; 110 (19):7796-81. PMCID: PMC3651481
BerbariN.F. #, Malarkey E.B. #, Yazdi S.M.Z. R., McNairA.D., CroyleM.J., KraftT.W., YoderB.K. Hippocampal and Cortical Primary Cilia are Required for Aversive Memory.PLoS One. 2014 Sep 3;9(9):e106576. doi: 10.1371/journal.pone.0106576. eCollection 2014. PMCID: PMC4153651
Berbari N.F., O'Connor A.K., Haycraft C.J., Yoder B.K. The Cilium as a Complex Signaling Center. Curr Biol. 2009 Jul 14; 1913):R526-35.
Berbari N.F., Pasek R.C., Yoder B.K. Neuronal Cilia in Obesity. Chapter in "Cilia in Neuroscience" Springer Press. 2013.