Associate Professor, Mathematical Sciences
Associate Professor, Mathematical Sciences
Professor Arciero's research in applied mathematics involves the development and analysis of ordinary and partial differential equation models of physiological phenomena including blood flow regulation, the immune response, inflammation, and cell migration. She is dedicated to using interdisciplinary approaches in her research and has established multiple collaborations with experimentalists and clinicians. Currently, Prof. Arciero is working on the following projects:
These collaborations will provide important insight into biological questions and demonstrate the depth and value of mathematical methods.
Previous postdoctoral and graduate work. Prof. Arciero developed theoretical models to investigate an inflammatory disease of the gut called necrotizing enterocolitis (NEC), which affects premature infants. NEC is thought to be related to an immature intestinal wall, an exaggerated inflammatory response, and impaired cell migration. She studied the contributions of these factors to NEC using two models: a compartmental ODE model that predicts conditions under which probiotic bacterial treatment may promote health (joint work with Bard Ermentrout, Jonathan Rubin, Yoram Vodovotz, and David Hackam's lab) and a two-dimensional continuum mechanical model of collective cell migration (joint work with David Swigon and Qi Mi).
Prof. Arciero studied metabolic regulation and autoregulation in the context of skeletal muscle. In addition to modeling vascular responses to pressure and shear stress, she modeled a conducted response mechanism in which ATP released by red blood cells at a site of oxygen demand causes an electrical signal to travel upstream along the vessel wall and trigger arteriolar vasodilation so that more blood is sent to the region of demand. She designed a representative segment ODE model that was based on the active and passive length-tension characteristics of vascular smooth muscle and was used to calculate the steady state vessel diameter and smooth muscle tone as oxygen consumption was increased from a resting to maximal exercise state. The model predicted an increase in flow that was consistent with experimental observations. She also examined the model's predictions of limit cycle oscillations in vessel diameter as a potential mechanism for vasomotion (joint work with Timothy Secomb).
35. Fry, B.C., Harris, A., Siesky, B., Arciero, J.C. Blood flow regulation and oxygen transport in a heterogeneous model of the mouse retina. Mathematical Biosciences. 329. (2020). https://doi.org/10.1016/j.mbs.2020.108476
34. Harris, A., Guidoboni, G., Siesky, B., Mathew, S., Verticchio Vercellin, A.C., Rowe, L., Arciero, J.C., “Ocular blood flow as a clinical observation: value, limitations, and data analysis.” Progress in Retinal and Eye Research. 78 (2020) https://doi.org/10.1016/j.preteyeres.2020.100841
33. Shughoury, A., Matthew, S., Arciero, J.C., Wurster, P., Adjei, S., Ciulla, T., Siesky, B., Harris, A. “Retinal oximetry in glaucoma: investigations and findings reviewed.” Acta Ophthalmologica 98(6):559-571. doi: 10.1111/aos.14397 (2020)
32. Zhao, E., Barber, J.O., Burch, M., Unthank, J., Arciero, J.C. “Modeling acute blood flow responses to a major arterial occlusion.” Mircorcirculation. https://doi.org/10.1111/micc.12610 (2020).
31. Arciero, J.C., Lembcke, L., Burch, M., Franko, E., Unthank, J. “Assessing the hemodynamic contribution of capillaries, arterioles, and collateral arteries to vascular adaptations in arterial insufficiency.” Microcirculation. 27(2):e12591. (2020)
30. Arciero, J.C., Carichino, L., Cassani, S., Guidoboni, G. “Mathematical modeling of blood flow in the eye” to appear in Mathematical modeling of ocular fluid dynamics. From theory to clinical applications. Springer. 2019
29. Fry, B.C., Coburn, B.E., Whiteman, S., Harris, A., Siesky, B., Arciero, J.C. Predicting retinal tissue oxygenation using an image-based theoretical model. Mathematical Biosciences. 305:1-9. 2018.
28. Arciero, J.C., Causin, P., Malgaroli, F. Mathematical methods for modeling the microcirculation. AIMS Biophysics. 4(3): 362-399. doi: 10.3934/biophy.2017.3.362. 2017.
27. Raimondi, G., Wood, K., Perelson, A.S., Arciero, J.C. Editorial: Transplant rejection and tolerance—Advancing the field through integration of computational and experimental investigation. Frontiers in Immunology. 8:616. 2017
26. Arciero J.C., Maturo A., Arun A., Chol Oh B., Brandacher G., and Raimondi G. Combining Theoretical and Experimental Techniques to Study Solid Organ Transplant Rejection. Frontiers in Immunology. (under review, 2016)
25. Cassani, S., Arciero, J.C., Guidoboni, G., Siesky, B., Harris, Al. Theoretical predictions of metabolic flow regulation in the retina. Journal for Modeling in Ophthalmology, (submitted February 2016).
24. Carichino, L., Harris, A., Guidoboni, G., Siesky, B.A., Pinto, L.A., Vandewall, E., Olafsdottir, O.B., Hardarson, S.H., Van Keer, K., Stalmans, I., Stefansson, E., Arciero, J.C. A theoretical investigation of the increase in venous oxygen saturation levels in glaucoma patients. Journal for Modeling in Ophthalmology, 1(1):64-87, 2016.
23. Wentz, S., Seizys, C., Guidoboni, G., Arciero, J.C., Hutchins, K., Siesky, B., Harris, A. “The role of blood flow in glaucoma” in Glaucoma Research and Clinical Advances: 2016 to 2018. pp. 243-260. Kugler Publications 2016
22. Prada D., Harris, A., Guidoboni, G., Siesky, B., Huang, A.M., Arciero, J.C. Autoregulation and neurovascular coupling in the optic nerve head. Survey of Ophthalmology. doi: 10.1016/j.survophthal.2015.10.004, 2015.
21. Cassani, S., Harris, A., Siesky, B., Arciero, J.C. Theoretical analysis of the relationship between changes in retinal blood flow and ocular perfusion pressure. J. Coupled Syst. Multiscale Dyn. 3(1):38-46, 2015.
20. Ford Versypt AN, Makrides E, Arciero J, Ellwein L, Layton AT. Bifurcation study of blood flow control in the kidney. Mathematical Biosciences 263:169-179, 2015
19. Arciero J, Ellwein L, Ford Versypt AN, Makrides E, and Layton AT. Modeling blood flow control in the kidney. IMA Volumes in Mathematics and its Applications, 158:55-73, 2015
18. Arciero, J.C.,“Modeling blood flow autoregulation in the retina” in Integrated multidisciplinary approaches in the study and care of the human eye. Kugler Publications 2014.
17. Guidoboni, G., Harris, A., Cassani, S. Arciero, J.C., Siesky, B., Amireskandari, A., Tobe, L., Egan, P., Januleviciene, I., Park, J. Intraocular pressure, blood pressure, and retinal blood flow autoregulation: A mathematical model to clarify their relationship and clinical relevance. Invest. Ophthalmol. Vis. Sci. 55:4105-4118, 2014.
16. Arciero, J.C., Harris, A., Siesky, B.A., Amireskandari, A., Gershuny, V., Pickrell, A., Guidoboni, G. Theoretical analysis of vascular regulatory mechanisms contributing to retinal blood flow autoregulation. Investigative Ophthalmology and Visual Science. 54(8):5584-5593, 2013; doi: 10.1167/iovs.12-11543.
15. Guidoboni, G., Harris, A., Arciero, J.C., Siesky, B.A., Amireskandari, A., Gerber, A.L., Huck, A.H., Kim, N.J., Cassani, S., Carichino, L. Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents. J. Coupled Syst. Multiscale Dyn. 1:1-21, 2013
14. Nguyen, T., Arciero, J., Piltz, J., Hartley, K.D., Rickard, T., Denton, R. Kinetic study of competitive catalytic transfer hydrogenation on a multifunctional molecule: 4-benzyloxy-4’-chlorochalcone. Reaction Kinetics, Mechanisms and Catalysis. doi:10.1007/s11144-013-0627-5 (2013)
13. Sarmah S., Muralidharan P, Curtis C, McClintick J. N, Buente B, Holdgrafer D, Ogbeifun O, Olorungbounmi O, Patino L, Lucas R, Gilbert S, Groninger E, Arciero J, Edenberg H. J., and J. A. Marrs. Ethanol exposure disrupts extraembryonic microtubule cytoskeleton and embryonic blastomere cell adhesion, producing epiboly and gastrulation defects. Biology Open, doi: 10.1242/bio.20135546, 2013.
12. Arciero, J.C., Ermentrout, G.B., Siggers, R., Afrazi, A., Hackam, D., Vodovotz, Y., Rubin, J. Modeling the interactions of bacteria, the immune response, and Toll-like receptors in necrotizing enterocolitis. Journal of Theoretical Biology. (2013) doi:10.1016/j.jtbi.2012.12.002
11. Harris A, Guidoboni G, Arciero JC, Amireskandari A, Tobe L, Siesky BA. Ocular Hemodynamics and Glaucoma: The Role of Mathematical Modeling, European Journal of Ophthalmology. 23(2):139-146, 2013
10. Arciero, J.C., Mi, Q., Branca, M., Hackam, D., Swigon, D. Using a continuum model to predict closure time of wounded intestinal epithelial cell layers. Wound Repair and Regeneration. 21(2):256-265, 2013
9. Arciero, J.C., Swigon, D. “Equation-based modeling of wound healing and collective cell migration” in Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer Science+Business Media. 2012
8. Arciero, J.C., Barber, J.B., Kim, M. “Modeling host-pathogen interactions in necrotizing enterocolitis” in Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer Science+Business Media. 2012
7. Arciero, J.C. and Secomb, T.W. Spontaneous oscillations in a model for active control of microvessel diameters. Mathematical Medicine and Biology (2011) doi:10.1093/imammb/dqr005
6. Arciero, J.C., Mi, Q., Branca, M.F., Hackam, D.J., Swigon, D. Continuum Model of Collective Cell Migration in Wound Healing and Colony Expansion. Biophysical Journal 100:1-9, 2011
5. Arciero, J.C., Ermentrout, G.B., Upperman, J.S., Vodovotz, Y., Rubin, J.E. Using a Mathematical Model to Analyze the Role of Probiotics and Inflammation in Necrotizing Enterocolitis. PLoS ONE 5(4): e10066. doi:10.1371/journal.pone.0010066, 2010
4. Arciero, J.C., Begg, R., Wilkie, K., et al. A Mechanism for Ventricular Expansion in Communicating Hydrocephalus. Proceedings of the OCCAM-Fields-MITACS Biomedical Problem Solving Workshop, 2009
3. Arciero, J.C., Carlson, B.E., Secomb, T.W. Roles of oxygen-dependent ATP release by red blood cells and conducted responses in metabolic regulation of blood flow. Am J Physiol Heart Circ Physiol 295: H1562-H11571, 2008
2. Carlson, B.E., Arciero, J.C., Secomb, T.W. Relative influence of myogenic, shear-dependent, and conducted responses on vascular autoregulation. Am J Physiol Heart Circ Physiol 295: H1572-H1579, 2008.
1. Arciero, J.C., Jackson, T.L., Kirschner, D.E. A mathematical model of tumor immune evasion and siRNA treatment. Discrete Contin. Dynam. Sys. 4(1):39-58 2004.