Haibo Ge Ph.D.
Associate Professor, Chemistry
Ph.D. University of Kansas, 2006
Postdoctoral Fellow, The Scripps Research Institute, 2006-2009
Organic Chemistry I (C341), Organic Chemistry II (C342), Synthetic Organic Chemistry (C652), Synthetic Medicinal Chemistry (C696)
Research in our group focuses on the development of metal-catalyzed carbon-carbon and carbon-heteroatom bond formation through C-H activation and total synthesis and structure-activity relationship studies of biologically active natural products. Current research programs in our laboratory include: 1) palladium-catalyzed C-H functionalization: investigation of novel transformations on aromatic and non-aromatic heterocycles, as well as metal-catalyzed cascade reactions; 2) total synthesis and structure-activity relationship studies of ascochlorin as an inhibitor of activator protein-1 (AP-1) for selective cytotoxicity in estrogen receptor-negative breast cancer; 3) synthesis and structure-activity relationship studies of aplysamine 6 to inhibit a novel target isoprenylcysteine carboxyl methyltransferase (ICMT).
Yang,k.; Li, Q.; Liu, Y.-B.;Li, G.-G.;Ge, H.-B. Catalytic C−H arylation of aliphatic aldehydes enabled by a transient ligand. J. Am. Chem. Soc. 2016, 138, 12775-12778.
Liu, Y.-B.; Ge, H.-B. Site-selective C–H arylation of primary aliphatic amines enabled by a catalytic transient directing group. Nat. Chem. 2016, in press, doi:10.1038/nchem.2606.
Wu, X.-S.; Zhao, Y.; Ge, H.-B. Direct aerobic carbonylation of C(sp2)−H and C(sp3)−H bonds through Ni/Cu synergistic catalysis with DMF as the carbonyl source. J. Am. Chem. Soc. 2015, 137, 4924-4927
Wu, X.-S.; Yang, K.; Zhao, Y.; Sun, H.; Li, G.-G.; Ge, H.-B. Cobalt-catalyzed site-selective intra- and intermolecular dehydrogenative amination of unactivated sp3 carbons. Nat. Commun. 2015, 6, 6462-6468.
Wu, X.-S.; Zhao, Y.; Ge, H.-B. Nickel-catalyzed site-selective alkylation of unactivated C(sp3)−H bonds. J. Am. Chem. Soc. 2014, 136, 1789-1792.
Wu, X.-S.; Zhao, Y.; Zhang, G.-W.; Ge, H.-B. Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)−H bonds. Angew. Chem. Int. Ed. 2014, 53, 3706-3710.
Zhang, G.-W.; Zhao, Y.; Ge, H.-B. Copper-catalyzed aerobic dehydrogenative cyclization of N,N-dimethylhydrazones via sp3 C−H bond functionalization. Angew. Chem. Int. Ed. 2013, 52, 2559-2563 (10.1002/anie.201209618).
Zhang, G.-W.; Miao, J.-M.; Zhao, Y.; Ge, H.-B. Copper-catalyzed aerobic dehydrogenative cyclization of N-methyl-N-phenylhydrazones: Synthesis of cinnolines. Angew. Chem. Int. Ed. 2012, 51, 8318-8321 (10.1002/anie.201204339).